Reproductive Tract Lesions in Male Mice Treated Neonatally with Tamoxifen1
نویسندگان
چکیده
منابع مشابه
Testosterone levels and histological features of reproductive glands in adult male rats treated neonatally with tamoxifen.
OBJECTIVE In this study we examined the possibility that demasculinization produced by the neonatal administration of tamoxifen is accompanied by a decline in plasma levels of testosterone during adulthood. METHODS Wistar male rats received either a treatment with 12.5 microg/kg of tamoxifen during the first eight days of age or a treatment with 100 microg/kg of tamoxifen for five days. Each ...
متن کاملProliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol.
Prenatal exposure to diethylstilbestrol (DES) is associated with reproductive tract abnormalities, subfertility and neoplasia in experimental animals and humans. Studies using experimental animals suggest that the carcinogenic effects of DES may be transmitted to succeeding generations. To further evaluate this possibility and to determine if there is a sensitive window of exposure, outbred CD-...
متن کاملUterine carcinoma in mice treated neonatally with tamoxifen.
The induction of preneoplastic and neoplastic lesions by the widely used antiestrogen Tamoxifen was studied in female mice. Outbred CD-1 mice were treated with Tamoxifen (1, 2, 5, 10, 25 or 50 microg/pup/day) for the first 5 days after birth. At 14-17 months, reproductive tract tissues were examined for pathological changes. In the ovary, corpora lutea were lacking while cysts were quite common...
متن کاملUterine adenocarcinoma in mice treated neonatally with genistein.
The developing fetus is uniquely sensitive to perturbation with estrogenic chemicals. The carcinogenic effect of prenatal exposure to diethylstilbestrol (DES) is the classic example. Because phytoestrogen use in nutritional and pharmaceutical applications for infants and children is increasing, we investigated the carcinogenic potential of genistein, a naturally occurring plant estrogen in soy,...
متن کاملVisualization by light and scanning electron microscopy of reproductive tract lesions in female mice treated transplacentally with diethylstilbestrol.
Pregnant female mice were exposed to diethylstilbestrol or 11 beta-methoxy-17 beta-estradiol on Days 9 to 16 of gestation. The female offspring of these animals were then examined for reproductive tract abnormalities. Scanning electron microscopic and histological evaluation of these specimens demonstrated reproductive tract lesions in all treatment groups when compared to matched control mice....
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1987
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod37.1.113